Medipolis Medical Research Institute

Medipolis Medical Research Institute is a non profit corporation to contribute to medical improvement and health enhancement through research, diagnosis, and treatment of chronic disease derived from cancer and vascular diseases, along with practical research in preventive medicine and mental health.

Medipolis Proton Therapy and Research Center

At Medipolis Proton Therapy and Research Center, we aspire to improve our patient's quality of life domestically and oversea by practicing fundamental and low-impact cancer treatment using proton therapy.

We are located in the southern part of Japan, Ibusuki, an area famous for generous hospitality. "Medipolis Ibusuki" is a project of cooperation among government, industry, and academia to promote "Medicine that radiates from Southern Kyushu to the rest of the world." The facilities include Medipolis Proton Therapy and Research Center that provides cutting edge treatment, a clinic that practices integrated and holistic medicine, spas, a resort hotel, and nature trails and a gym for health enhancement.

Proton Therapy

What is Proton Therapy?

A proton beam is a flow of particles generated from hydrogen gas. By using an accelerator which is called Synchrotron, which will accelerate these particles to near the speed of light, cancer can be locally irradiated. The proton beam has the ability to focus and affect cancer lesions with minimal impact on surrounding muscle and tissues. Thus it is possible to minimize detrimental effects on normal healthy tissues. More than 100,000 cancer patients have been treated world-wide with favorable results.

The radiation used for cancer treatment is divided into photon and ion beams. The photon beam is an electromagnetic wave, which is used in traditional radiation therapy such as X-rays and gamma rays. Ion beam radiation uses hydrogen (proton) or carbon ions, and the radiation therapy taking advantage of these particles is called "particle therapy."

One of the characteristics about particle therapy is that the particle beam has a physical nature of energy emission called the "Bragg peak," by which it can inflict lethal, concentrated damage on cancer cells while keeping radiation stress of normal tissue in the minimum level.

Difference between X-ray and particle beam treatments

Compared with X-rays, proton beam treatment can exactly irradiate a strong beam onto the cancer lesion and focus its energy. It has been shown that the radiation of normal, healthy tissue is around 2 to 3 times less compared with normal X-ray therapies. This significantly decreases the risk of secondary malignancies, which is also beneficial for pediatric patients.

What happens in the body after proton irradiation?

When the body is irradiated with a proton beam, the beam can reach a tumor with a minimal side effect on surrounding normal tissues. It then attacks DNA in the core of the cancer cells. The cancer cells damaged by the proton beam are unable to reproduce.

Benefits of proton therapy

Proton treatment offers the cancer patient a better quality of life during and after treatment for the following reasons.

  • Non-invasive procedure therefore no pain
  • Much more accurate than other radiation therapies
  • Higher doses directed at the cancer tumor without damage to surrounding tissue
  • Lower risk of side effects when compared to other therapies
  • Reducing the likelihood of secondary tumors caused by treatment
  • Enabling daily treatment on an outpatient basis
  • No requirement of long and painful recovery time.
  • Little or no effect on the patient physical and psychological state

Because of the above, proton is an excellent treatment for all age groups

Our Facilities

The Medipolis Proton Therapy and Research Center was founded in early 2008. The construction of a new state-of-the-art proton beam therapy system started one year later. Finally in January 11th, 2011 the first patient has been treated. Since then many patients have been successfully treated. Medipolis is one of the most advanced and high technologized cancer clinics in the world.

The functions of facilities

  • Gantry Irradiation Rooms (3 rooms)
  • The Gantry is a device for focusing the proton beam. The 180-ton device rotates 360 degrees around the patient, and can deliver the proton beam from any direction.
  • Synchrotron
  • It is a donut-shaped device that accelerates the proton beam to about 2/3 (or 70%) the speed of light.
  • Operation / Control Room
  • A room where the technologists control the proton beam irradiation.
  • Pre-treatment & Diagnostic Room
  • A room for confirming the exact location of the cancer before the beginning of treatment.


Our facilities are constantly maintained by a team of specialized engineers. They check, calibrate and monitor every machine through on a daily basis. Moreover the treatment is halted for two to three days to perform a full deep check and maintenance of the whole machinery. This ensures the highest level of safety so that our doctors and you can fully concentrate on your cancer treatment.

Our Chairman and Physicians

Ryoichi Nagata, M.D., Ph.D.
Chairman of Medipolis Medical Research Institute
Ph.D. in Medicine (Kagoshima University). Masters in Buddhist Tantrism (Koyasan University). Executive Director of the Japanese Society of Preventive Medicine, Supervisory Doctor of the Japanese Society of Clinical Pharmacology and Therapeutics, Member of Management Council of Kagoshima University, Councilor and guest professor of St. Marianna University School of Medicine, Guest professor of University of Maryland, Guest professor of Tokyo Medical University, Guest professor of Hokkaido University, Clinical professor of Kochi Medical School, Guest professor of Koyasan University. Faculty of Pharmaceutical Medicine of the Royal Colleges of Physicians of the United Kingdom (FFPM). "Comfortable Creation Award" of the Japanese Joint Association of Labor Standard, "Local Activation Contributing Company Award" of Nikkei Inc. (Co-host Ministry of Land, Infrastructure, Transport, and Tourism), "The first place of Economic and Industry Award" of Kagoshima Camber of Commerce and Industry, "54th Southern Japanese Culture Award in Industry" of Minami Nihon Shinbun, "Honorary Citizen" of Gaoyao, Guangdong, China, "Honorary Consul" of the Kingdom of Bhutan. CEO, Shin Nippon Biomedical Laboratories, Ltd.

Yoshio Hishikawa, M.D., Ph.D.
Director of Medipolis Proton Therapy and Research Center
Ph.D., School of Medicine, Kobe University. Radiologist. Certifying physician of radiation oncology. Chief courier of the Japan Clinical Study Group of Particle Therapy. Representative of the Japan Radiological Society. Representative of the Japanese Society for Therapeutic Radiology and Oncology. Chairperson of the Annual Meeting of the Japanese Society for Therapeutic Radiology and Oncology in 2011. Visiting Professor of Kobe University. Visiting Professor of Kagoshima University. Invited Professor of Osaka University. Awarded the Brachytherapy Award of European Society of Radiology in 1990. Former President and Honorary Director of Hyogo Ion Beam Medical Center.

Takashi Ogino, M.D.
Acting Director of Medipolis Proton Therapy and Research Center
American Society for Therapeutic Radiology and Oncology (ASTRO), European Society for Therapeutic Radiology and Oncology (ESTRO), American Society of Clinical Oncology (ASCO)

Takeshi Arimura, M.D.
Director of Diagnosis and Treatment Department
American Society for Radiation Oncology


We are making efforts to proton therapy for breast cancer.

Breast cancer is one of the most prevalent malignant cancers among women, and it is expected to increase in young women in the future. Currently the standard treatment for patients with early breast cancer consists of surgery and radiotherapy. Understandably, there are some women who are very reluctant to undergo this invasive alternative.

In order to investigate whether proton therapy is helpful for these patients, we started a research group (Society for Proton Therapy for Breast Cancer) with breast cancer treatment specialists in the Kyushu area. Our first research objective is to develop a breast cancer therapy device and put it into practical use. One of the 3 treatment rooms is used only for the study of early breast cancer treatment.

Location and Accommodation


Medipolis is located in Ibusuki on the Kyushu island in the south of Japan. Ibusuki is famous its sand baths, natural hot springs and rich food. A perfect place for generous hospitality. Ibusuki is located on the southeastern tip of the Satsuma peninsula, which itself is located on the south area of Kyushu. Mild weather and various greenery give this place a tropical atmosphere. Beside famous steam sand baths, which are heated by natural subterranean geysers, a variaty of beautiful nature spots can be found within short distance. Mt. Kaimon, which is 924 meters high and selected as one of the hundred best mountains in Japan, offers numerous laid-back hiking trails and fascinating view spots. Moreover a visit to Lake Ikeda, which is Kyushu's biggest lake, is highly recommended.


Medipolis is located on the top of a hill. More than 1 million sqm include the Ibusuki Bay Terrace Hotel, a number of sport facilities, our organic garden and lots of untouched nature making it the perfect place to relax.

Accommodation: Ibusuki Bay Terrace Hotel & Spa

Adjacent to Medipolis is the Ibusuki Bay Terrace Hotel & Spa, a marvelous resort hotel for relaxation and recuperation. There are 3 types of rooms (Japanese style, Western style and suite). Each one offers a magnificent view over Ibusuki, the Kinko Bay, the Osumi peninsula, and the distant Sakurajima volcano [cf.]. Our restaurant serves a variety of local "Satsuma" cuisine. [cf.] Ingredients are sourced from the local ocean and farms. Fresh fruits and vegetables come from our very own organic gardens.

Relaxation experiences

Experience the best of Japanese culture in our Onsen (natural hot spring) with a full view of Kinko Bay and the distant Osumi peninsula. Or enjoy our ceramic spa (the next step in sand bath relaxation), private open air mineral baths can be enjoyed in the fragrance of the open woods, bedrock baths, and space for relaxation and stress relief await you. We have an illuminated, artistically designed experience called the Ascension to aid healing; it allows you to relax lying down surrounded by 20,000 LEDs, and healing music.


Massage by aroma therapists and certified chiropractors is conducive to the improvement of health. Exercise facilities include a Japanese style ground golf course, tennis courts, pool, gymnasium, weight training room with machines and free weights, and an area for stretching.

Beautiful nature

You can walk along the nature trail and enjoy the sunshine filtering through the trees, and you will come to an observation deck with a grand 360 degree panoramic view. From this location, you can see Ibusuki City, Osumi peninsula, and if the weather permits, you can also see Sakurajima mountain, and to the south the remote islands (Yakushima, Tanegashima and Iojima). You can enjoy the Medipolis organic garden, the outdoor foot bath , a row of cherry blossom trees, and a hydrangea trail.